Resources for Fatigue & PEM
What is Fatigue and Post-Exertional Malaise?
Fatigue is one of the most common reasons for seeking medical care. It’s a general term that refers to having insufficient energy to carry out desired tasks.
- Cognitive and body fatigue occurs with many conditions, including myalgic encephalomyelitis (ME), chronic fatigue syndrome (CFS), fibromyalgia (FM), environmental sensitivities (ES), long COVID and chronic pain.
- It’s an internal experience that’s hard to measure.
- For this reason, medical professionals often dismiss complaints of fatigue or, if taken seriously, do not fully investigate them.
- Post-exertional malaise (PEM) refers to a prolonged worsening of symptoms after minimal physical, emotional or mental exertion.
- It’s the hallmark symptom of ME and CFS and is common in long COVID and fibromyalgia.
- PEM is triggered by ordinary activities that healthy people tolerate.
- Typically, PEM begins 12 to 48 hours after the activity that triggers it and, by definition, lasts more than 24 hours.
- It’s highly variable and may persist much longer.
- PEM is especially disabling because increasing activity increases PEM, which can last for days to weeks or, for the severely ill, even forever. This stops people in their tracks.
Pacing is the most effective management strategy for people with fatigue and PEM.
- Pacing is accommodating your activities to your energy level, not the other way around.
- Core pacing skills—such as breaking activities into small chunks, setting a timer to avoid overdoing it, and resting before and after tiring activities—can help people build sustainable, predictable energy and have a better quality of life.
Online Courses
Membership to Live Sessions
Live! with Dr. Stein
Evidence-based presentations and Q&A with Dr. Stein. Credible, science-based, and cutting edge information about how to live longer and healthier.Â
Self-Study Course
Pathways to Improvement
Learn to take charge of your health to help you feel and live better. Pacing and working within your energy envelope can make a big difference. Self-management works!
More DetailsSelf-Study Course
Pathway 3: Sleep
Better sleep means less pain and more comfort. Wake more refreshed and have more energy to enjoy life by learning proven self-management strategies for more effective sleep.Â
More DetailsWebinars (recordings)
Pacing to Boost Energy and Avoid Crashes
Dr. Alison Bested explains what pacing is, why pacing is important to prevent worsening of illness, and tried and tested pacing strategies to stop crashing and gain energy.
More DetailsThe Power of Neuroplasticity
Dr. Howard Schubiner, an internist and clinical professor at MSU, shares evidence-based steps to unlearn chronic pain, depression, anxiety and fatigue, and helps you determine if your condition may respond to Pain Reprocessing Therapy.
More DetailsDeep Pacing
Dr. Stein explains DEEP pacing—providing strategies for attending holistically to the mind and body, to stabilize your energy, make your life and health more predictable, and give you more control.Â
More DetailsCauses & Treatment
Dr. Neil Nathan explains how to solve underlying causes of ME, CFS, FM and ES. Learn strategies to recover from mold and infections that make people sensitive and reactive.
Books

Let Your Light Shine Through, Second Edition
In this manual, Dr. Stein shares the strategies she has found to be the most successful for patients in her 35-year medical practice working with ME, CFS, FM, ES, chronic pain and long COVID. Readers are guided through a 286-page, 4-month program specific to these conditions. Let Your Light Shine Through is filled with practical, no-to-low-cost management suggestions, tools and resources.
The second edition has updated disease definitions, research updates, online resources, peer-reviewed references, and a bonus chapter, New and Future Directions, with new strategies to leverage the body's innate ability to heal.
More DetailsÂ

More Light
Building upon Let Your Let Shine Through, More Light contains up-to-date, science-based information, clinical approaches, and affordable interventions you can do on your own. Currently, only individual chapters are available at affordable prices. Choose the subjects tailored specifically to your health needs. Current topics are Self-management, Diagnosis, Biology of Change, Sleep, and Energy and Activity.
More DetailsThe Dr. Eleanor Stein Podcast
Episode 12: Movement as Medicine: Rebuilding Strength Without Crashing with guest Caroline Jordan
Episode 3: The 5 Types of Fatigue and How to Treat Them with guest Dr. Jenny Tufenkian
These are the most current Podcasts on the topic of fatigue and PEM.
For all Podcasts, click here.
Recommended Free VideosÂ
Using Wearable Trackers to Pace Better and Decrease PEM
Did you know that the data you get from your wearable tracker can help you improve your pacing and energy levels?
In this presentation to ME International on May 10, 2024, Dr. Stein explains
- the contributors to and symptoms of post-exertional malaise (PEM)
- basic pacing strategies to keep your energy stable and minimize crashes
- how to use heart rate and heart rate variability data from your wearable tracker to improve pacing
- lots of Q&A
Podcast with Dr. Courtney Craig
In this episode, Dr. Courtney Craig and I discuss our shared experience of how a diagnosis of ME/CFS led us, professionally, to help others manage the condition. I describe how self-management strategies can impact biology and, therefore, improve patients' lives.
Spoonie Radio is a Chronic Fatigue Syndrome & Fibromyalgia Podcast highlighting effective treatment strategies as well as insight from clinicians, researchers, and advocates. This show is brought to you by Dr. Courtney Craig, recovered CFS patient and clinician. Click on the link below to listen to the podcast www.drcourtneycraig.com.
Blog Posts
Fatigue and Post-Exertional Malaise Part 1Â (parts 2-4 at the end of part 1)
Could the Mitodicure Pill be the Long-Awaited Answer for ME/CFS and Long COVID?
How to Improve Mitochondrial Function
Objective Evidence of Post Exertional Malaise and Brain Fog in ME/CFS
Classic Pacing with Ingebjørg Midesem Dahl
These are the most current Blogs on the topic of fatigue and PEM.
For all Blogs, click here.