Episode 17: What Allergies, Anxiety and Fatigue Have in Common—The Mast Cell Connection with guest Dr. Theo Theoharides

Do you struggle with random flares, brain fog, or sensitivities that never fully respond to antihistamines? In this episode, I talk with Dr. Theo Theoharides, a leading mast cell researcher, about mast cell activation—a hidden driver behind many chronic symptoms.

In this conversation, we explore
  • How mast cell activation differs from classic allergies
  • Why it can cause brain fog, fatigue, and mood changes
  • Natural and evidence-based strategies to calm mast cells
  • Testing, treatment, and supplement tips that actually work

If you’ve tried everything and still feel stuck, this conversation may offer the clarity and next steps you need.

     (00:00) Introduction & Key Takeaways
     (01:11) Podcast Overview and Guest Introduction
     (03:27) Dr. Theoharides' Background
     (06:01) Understanding Mast Cell Activation Categories
     (10:28) Types of Mast Cell Activation & Diagnostic Challenges
     (12:24) Symptoms & Diverse Presentations
     (17:36) Neuropsychiatric and Brain Symptoms
     (23:00) Why Mast Cell Activation Is Increasing
     (27:39) New Triggers: Toxins, Mold, and Preservatives
     (34:33) Gut-Related Symptoms & Testing Strategies
     (40:08) Diagnostic Approaches and Treatment
     (46:12) Flavonoids and Natural Remedies
     (51:00) Diet, Probiotics, and Managing Triggers
     (54:05) Testing, Food Intolerance, and When to Treat
     (57:04) Common Misunderstandings & Take-Home Messages
(01:00:38) When to Suspect Mastocytosis
(01:01:17) Tips on Further Testing and Resources
(01:02:18) Wrap-Up and Where to Learn More

Resources mentioned Dr. Theo Theoharides’ official site and publications www.drtheoharides.com/

Dr. Theoharides's Social Media 
Dr. Theoharides' Instagram: @dr.theoharides  
Algonot's Instagram: @algonot  

Algonot liposomal formulations referenced in the interview (PureLute, NeuroProtect, FibroProtect), discussed for their specific flavonoid blends and liposomal delivery.  

A Note on Safety and Next Steps 
If you suspect mast cell activation, begin with a careful history and targeted testing, and introduce supplements gradually while tracking symptoms. If you have complex medical issues (for example, cancer or known enzyme polymorphisms), coordinate care with a clinician experienced in mast cell disorders.  

Welcome to my podcast!
I am a retired medical doctor and psychiatrist specializing in chronic complex diseases. With over 33 years of experience, I have worked with thousands of patients, integrating both conventional and integrative approaches to enhance health and function. Since retiring from medical practice at the end of 2022, my passion is to help others find healing by sharing science-based, no-to-low-cost health strategies.

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